Homobifunctional Maleimides

 

Product No. Name Pkg Price
 
46344









 		1,2-bis-Maleimidoethane; (Molbio Ultra, 99+%)
C10H8N2O4; Mr=220.18; mp  193-194 °C
Spacer Arm length:  8.0 Å.

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● Short, sulfhydryl reactive homobifunctional crosslinking reagent.  Crosslinks to 9.9 Å.
● Maleimide group labels sulfhydryls optimally between  pH 6.5-7.5.

Storage 0-4 °C

 100mg
250mg








 $110.00
$247.50
98686









 		1,4-bis-Maleimidobutane; (BMB)  99 %
C12H12N2O4; Mr=248.24; mp 196-197 °C (Sublm 180 °C)
Spacer Arm length:  10.9 Å.

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● Short, sulfhydryl reactive homobifunctional crosslinking reagent.

Storage 0-4 °C

 100mg
250mg








 $110.00
$247.50
98676











 		1,6-bis-Maleimidohexane; (BMH)  99+ %
 C14H16N2O4; Mr=276.29; mp  136-137 °C
Spacer Arm length:  16.1 Å.

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● Sulfhydryl reactive homobifunctional crosslinking reagent.1
● Maleimide group forms stable thioether linkages with substrates.  Crosslinks efficiently with sulfhydryls at pH 6.5-7.5.

 1.  Partis, M.D., et.al. (1983) J. Prot. Chem. 2, 263-277.

Storage 0-4 °C

 100mg
250mg










 $82.50
$200.00
98222













 		1,4-Phenylene dimaleimide
 [3278-31-7]; C14H8N2O4; Mr=268.23; mp  >300 °C

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● Homobifunctional protein crosslinking reagent.1
● Useful for antibody-enzyme conjugation.2
1.  Knight, P., et.al. (1979) Biochem. J. 179-191.
2.  Yoshitake, S., et.al. (1979) Scand. J. Immunol. 10, 81.

Storage 0-25 °C

 2.0g













 $27.50
98220







 		1,2-Phenylene dimaleimide
 [13118-04-2]; C14H8N2O4; Mr=268.23; mp 250-252 °C

● Short, sulfhydryl reactive homobifunctional crosslinking reagent for protein crosslinking.1


 1.  Knight, P., et.al. (1980) Biochemistry 19, 4682.

Storage 0-25 °C

 2.0g







 $27.50
46578











 		Dithio-bis-maleimidoethane; (DTME)
 C12H12N2S2O4; Mr=312.37; mp 124 °C
Spacer Arm length:  13.3 Å.

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● Sulfhydryl reactive and cleavable homobifunctional crosslinking reagent.
● Dimeric products are cleavable with DTT, DTE, or TCEP.1


 1.  Han, J.C., et.al. (1994) Anal. Biochem. 220, 5-10.

Storage 0-4 °C

 100mg











 $247.50
46988










 Maleimidopropionic acid maleimidomethyl ester; (MMP)
 C12H10N2O6; Mr=278.22; mp  130 °C (Soften @ 127 °C)

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● Useful for crosslinking substrates to erythrocyte membranes.1
● Cleavable with 0.02 M hydroxylamine or mild base.
1.  Sato, S., et.al. (1981) J. Biochem. 1177-1185.

Storage 0-4 °C

 50mg










 $125.00
98424







 		(BMME)
bis-Maleimidomethylether, (Molbio Ultra, 99+%)
[15209-14-0]; C10H8N2O5; Mr=236.18; mp 129-130 °C

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● Ultra short homobifunctional crosslinking reagent specific for sulfhydryl groups.1

1.  Neblock, D.S., et.al. (1992) Bioconjugate Chem. 3, 126.

Storage 0-4 °C

 100mg







 $75.00
46777









 		BM(PEO)4
Syn:  1,11-bis-Maleimido-(PEO)4 (Molbio Ultra, 99+%)
 C16H20N2O7; Mr=352.34; mp 71-72 °C
Spacer Arm length:  17.8 Å.

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● Polyether chain imparts superior solubility properties in aqueous or organic solvents!
● Used to generate tumor-targeting Pharmaceuticals.1
● Water soluble!

1. DeNardo, S. J.; et. al. (2005) Bioconjugate Chem. 16, 113-121.

Storage 0-25 °C

 100mg









 $137.50
46788 










 		BM(PEO)3
Syn:  1,8-bis-Maleimido-PEO3 (Molbio Ultra, 99+%)
 C14H16N2O6; Mr=308.29; mp  99 °C
Spacer Arm length:  14.7 Å.

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● Polyether chain imparts superior solubility properties in aqueous or organic solvents!
● Water soluble!

Storage 0-25 °C

 100mg










 $104.50
98623

(HBVS)
Syn:  1,6-Hexane bis-vinylsulfone
C10H18S2O4; Mr=266.38; mp  93-94 °C
Spacer Arm length:  14.7 Å.

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● Hydrolytically stable vinylsulfone crosslinks sulfhydryl groups to 14.7 Å!
● Unlike maleimides, Michael addition to vinylsulfones does not generate stereoisomers.

Storage 0-4 °C

 50mg









 $110.00

 

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